The prevention paradox or the inequality paradox?

The prevention paradox or the inequality paradox?

In February this year, a new edition of Geoffrey Rose’s classical book Strategy of Preventive Medicine was published, with a commentary by Kay-Tee Khaw and Michael Marmot. The commentary summarizes the life and work of Geoffrey Rose, explains the main content and impact of the classical book and gives plenty of examples that illustrate the validity of Rose’s theses. Coincidentally, in the Febru...

Hypertension: the prevention paradox.

Exploiting the mTOR paradox for disease prevention

Activation of the mechanistic target of rapamycin (mTOR) is a common feature in most human malignancies [1]. Inhibition of mTOR by rapamycin and newly developed inhibitors has already shown promising antitumoral activity in a variety of experimental cancer models and in recent clinical trials [2, 3]. However, an increase in mTOR activity has also been related to aging, causing stem cells to und...

DDT and Malaria Prevention: Addressing the Paradox

BACKGROUND The debate regarding dichlorodiphenyltrichloroethane (DDT) in malaria prevention and human health is polarized and can be classified into three positions: anti-DDT, centrist-DDT, pro-DDT. OBJECTIVE We attempted to arrive at a synthesis by matching a series of questions on the use of DDT for indoor residual spraying (IRS) with literature and insights, and to identify options and opp...

Women and the Paradox of Inequality in the Twentieth Century

Throughout American history, male/female has defined an enduring binary embodied in access to jobs, income, and wealth.Women’s economic history shows how for centuries sex has inscribed a durable inequality into the structure of American labor markets that civil and political rights have moderated but not removed. This economic experience of women reflects the paradox of inequality in America: ...